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Some internal diseases also cause vertigo

In order to determine if compounds showed selective inhibition of TGR compared to human TrxR and GR, the IC 50 values for TGR were compared to those of human TrxR and GR either reported in literature or determined here (Table 4)

The first hit refers to early metabolic disturbances, including excessive triglyceride accumulation within hepatocytes, insulin resistance, hyperglycemia, and hyperlipidemialeading to steatosis

In addition to the fact that MASLD is the fastest increasing indication for liver transplantation 4 , it has also been associated with significant all-cause mortality and cardiovascular morbidity and mortality