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GLP-1 activation has several effects on your digestive system that directly cause GI symptoms: Delayed gastric emptying: Food stays in your stomach longer, causing fullness and sometimes nausea Altered intestinal motility: Changes in how quickly food moves through your intestines can cause either diarrhea or constipation Reduced appetite signals: Your brain receives signals to eat less, which changes your entire digestive rhythm Changes in bile acid secretion: This affects fat digestion and can contribute to loose stools Gut hormone changes: Multiple digestive hormones are affected, altering the normal digestive process Mounjaro Diarrhea: Causes, Duration, and Treatment Why Does Mounjaro Cause Diarrhea
Apart from these origins, other important sources of endogenous oxidants involve nitric oxide synthase, cytochrome p450, monoamine oxidase, various oxidoreductases such as mitochondrial respiratory chain (RC), xanthine oxidase, and enzymes responsible for infection and inflammatory responses to stimulate xenobiotic for instance NADPH oxidases [25]
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