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Drug-metabolising enzymes (DMEs) play an important role in scavenging the waste products of lipid metabolism and oxidative metabolism and maintaining homeostasis of liver 4,5 , consisted of groups of enzymes, such as glutathione S-transferases (GSTs)

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Combining a hepatically-challenged metabolism of bupropion with the general metabolic demands of tirzepatide therapy requires careful monitoring of liver enzymes and possibly reduced dosing of bupropion

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