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Potential Research Applications: Mitochondrial function and cellular energy metabolism studies Sirtuin pathway activation and NAD+ dependent enzyme research DNA repair mechanism and oxidative stress response models Redox signaling and cellular biochemistry investigations For laboratory research only

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Although some studies confirm the feasibility of exempting patients who achieve pCR after neoadjuvant systemic therapy under rigorous evaluation using ultrasound or MRI, 323,326,327 this approach is constrained by regional development levels and technological disparities

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