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Perry T, Greig NH: Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimers disease

Start with 1 teaspoon diluted in 8-10 ounces of water once daily, gradually increasing to 1-2 tablespoons per day if well-tolerated

Revised 2023

Primary Cellular Pathways FAK/Paxillin Signaling Cell Migration Enhancement BPC-157 significantly increases phosphorylation of focal adhesion kinase (FAK) and paxillin proteins in fibroblast cells, promoting enhanced cell adhesion and migration

However, given that large peptides like GLP-1 interact with both the extracellular and transmembrane domains of the GLP-1R ( 32 ), and that our small molecules were unlikely to recapitulate this complex binding mode, it was unclear whether the competition binding experiments with radiolabeled GLP-1 were providing an accurate measure of affinity ( 25 )

Ambrosone, C.B., Tang, L