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Otolaryngol Clin North Am

Here are some of the notable functions: Cellular Protection : By neutralizing free radicals, glutathione protects cells from oxidative damage, which is especially important during the postpartum period when the body is healing and adapting

To address this limitation, multimodal biomarkers have been developed, including fluid markers such as plasma GFAP and chitinase-3-like protein 1 (YKL-40) that differentially associate with amyloid versus tau pathology, positron emission tomography (PET) tracers targeting astrocytic MAO-B that provide complementary in vivo readouts and proteomic analyses identifying novel candidates such as VCAM1 and BST2 141,142,143,144

We have resolved the three-dimensional structure of FhGST-S1 in complex with its co-factor glutathione, in complex with a glutathione-cysteine adduct, and in a glutathione disulfide complex in order to initiate a research pipeline to mechanistically understand how FhGST-S1 functions within the host environment and to rationally design selective inhibitors

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PMID: 31806372 Nat Prod Commun2024 Mar 20