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Plant Cell 19, 37393759

This variation may explain why some TRT-treated men achieve excellent weight loss with GLP-1, while others see modest results despite optimized dosing

Thus, it appears important to evaluate vitamin B 12 status, as well as kidney function, in older individuals with elevated homocysteine levels prior to initiating homocysteine-lowering therapy

Dosage GLP-1 Medication is started at a low dose and gradually increased

5.4 Gastrointestinal Side Effects and Nutrient Loss Nausea and vomiting are well-documented adverse effects. Persistent vomiting or diarrhoea may: Increase electrolyte loss Reduce caloric intake Reduce dietary diversity However: These effects are typically transient and dose-related

The quality of each included RCT was assessed by the Cochrane Risk-of-Bias Tool 1.0