The current study demonstrates that A-anticalin dependent A monomer scavenging can repair neuronal and synaptic dysfunctions in mouse models of AD in vivo
Glutamine improves HSP70 and HSP27 expression [43, 44, 110] and acts not only as a modulator of the heat shock response but also as a competent inducer of HSF-1 expression, activating its transcription [93, 111, 112]
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BDNF signaling is frequently downregulated in neurodegenerative conditions, and strategies to restore its levels have demonstrated improvements in synaptic integrity and cognitive outcomes [129, 130]
3322-A METHANOBACTIN RESTORES BILIARY COPPER EXCRETION IN WILSON DISEASE RATS VISUALIZED BY 64Cu PET/MRI Emilie Munk 1 , Mikkel Holm Vendelbo 1 , Frederik Teicher Kirk 1 , Mette Irene Theilgaard Simonsen 1 , Aage Kristian Olsen Alstrup 1 , Tamara Rieder 2 , Tea Lund Laursen 1,3 , Peter Ott 1 , Hans Zischka 2,4 and Thomas Damgaard Sandahl 1 , (1)Aarhus University, (2)Technical University Munich, (3)Randers Regional Hospital, (4)Helmholtz Center Munich, German Research Center for Environmental Health Background: Methanobactins (MBs) are small peptides with a very high copper affinity currently under investigation in preclinical trials for the treatment of Wilson disease (WD)
