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Tirzepatide alone has demonstrated 2022% weight loss in Phase 3 trials

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Semaglutide works on GLP-1 only, while Retatrutide works on GLP-1, GIP, and glucagon together, so labs study it for stronger effects on appetite, insulin, and energy burn

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Semaglutide, though also causing gastrointestinal issues, typically results in fewer and less severe side effects