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As the developing chondrocytes repair the damaged and diseased cartilage, joint discomfort decreases, and mobility gradually improves

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2 The main sources of cellular ROS are mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and peroxisomes containing xanthine oxidase and the inducible form of nitric oxide synthase, which produce superoxide anion and nitric oxide, respectively