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HMGB1: A common biomarker and potential target for TBI, neuroinflammation, epilepsy, and cognitive dysfunction

So after the recent publication of a study indicating that statins can have a detrimental effect on GLP-1 secretion and insulin sensitivity, an important question quickly followed: should individuals on statins be concerned about these apparent effects on metabolic health

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287(3): 897902 Lowitt S, Malone JI, Salem AF, et al

PKM2 also decreased the inflammatory mediators produced by IL-1 stimulation accumulation (tumor necrosis factor- and IL-6), and downregulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase2 (COX-2) induced by IL-1