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Though the concept of a healthy microbiota is challenging to define, dysbiosis can usually be defined as a certain imbalance where the pathogenic species are dominant over beneficial symbionts and commensals (Hou et al

Knockout of GLP-1R could block the activation of Nrf2 and inhibit inflammation and oxidative stress (Tu et al., 2023)

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This dual role, known as antagonistic pleiotropy, beneficially suppresses tumor initiation early in life but detrimentally increases the risk of age-related pathologies, later