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146 This protective mechanism is exerted by the prevention of BH 4 oxidation by the increased superoxide

Supports immunity and antioxidant protection

It reduces oxidative stress, protects mitochondria, and supports DNA repair, slowing down the processes that lead to cellular aging and senescence

Autophagy in the physiological endometrium and cancer

Sigma) or an equivalent volume of DMSO (Sigma)

If tumor cells activate the homologous recombination repair pathway by upregulating key repair proteins (such as BRCA1/2, RAD51, etc.), they can efficiently repair these serious damages and thus escape chemotherapy induced cell apoptosis ( In summary, this mechanism plays an important role in chemotherapy resistance, revealing that inhibiting specific repair pathways (such as using PARP inhibitors to interfere with BER) may be a new strategy to overcome resistance ( 4.3 Relationship between tumor microenvironment and drug resistance The complexity and heterogeneity of the tumor microenvironment provide multiple protection mechanisms for tumor cells to escape drug attack and is a major culprit of tumor resistance