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1) Core toxicology: a narrow physiologic buffer at the top of the therapeutic range Metabolic pathway: ~9095% is detoxified via glucuronidation and sulfation

Ideally incorporate rigorous baseline and follow-up assessments: DEXA, body composition, visceral fat, renal function, endocrine panels, inflammatory biomarkers (IL-6, TNF-, SASP markers if available)

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Methaemoglobin cannot carry oxygen, so the RBCs functionality decreased

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