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Emerging as a promising treatment of rheumatoid arthritis as well, a landmark case published in Annals of the Rheumatic Diseases in 2024 described how a CD19-directed CAR-T infusion induced deep remission in a patient with polyrefractory rheumatoid arthritis, eliminating autoantibodies and restoring clinical function

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Lewy bodies are formed by the combination of alpha-synuclein with ubiquitin (Simone, 2008), neurofilament protein, and alpha B crystalline

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(2011) found a lack of association between low ventricular CSF orexin and sleepiness in PD, and a relation between high levels of orexin-A in PD associated with loss of REM muscle atonia (Bridoux et al., 2013), while Wienecke et al