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A limitation of these studies is the absence of stratification of heart failure patients based on ejection fraction, therefore additional clinical research specifically investigating the effects of GLP-1 receptor agonists in patients with heart failure with preserved ejection fraction (HFpEF) is warranted [94]

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Because your intestines can only absorb so much at once, and your kidneys continuously waste it, a single large daily dose would simply be excreted, leaving your heart and muscles unprotected for the rest of the day [11] [7]

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