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In a 2012 double-blind randomized controlled trial (N = 70 LOE2a), 500 mg of LC was administered daily to migraine patients for 12 weeks

Patients should be alert to: Persistent constipation , which may increase diverticular pressure New or worsening abdominal pain , especially if localised to the lower abdomen Changes in stool consistency or frequency Fever or systemic symptoms suggesting infection Communication with healthcare providers is vital

Butyrate's anti-inflammatory effects extend to fat tissue, helping maintain healthy adipocyte function and helping maintain adipose tissue balance and avoiding inflammatory changes that may affect insulin sensitivity

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