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This dose helps clinicians assess whether moving to a higher dose or staying at this one is more appropriate

Bibcode:2019PNAS..11613116B

doi: 10.1093/cvr/cvr242 45 de KloetADCahillKMScottKAKrauseEG

The most common side effects are gastrointestinal: nausea (30-44%), diarrhea (19-30%), constipation (10-24%), and occasional vomiting (9-24%)

The important thing is that the trajectory is established

The precipitation pH (pHp) These two properties of pKa and water solubility are brought together by combining them with Henderson Hasselbalch analysis to give the precipitation pH that allows us to determine the expected amount of niclosamide in solution across the whole pH range