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Multiple studies show that serial corticosteroid injections are associated with tendon degeneration, reduced collagen quality, and increased risk of tendon rupture

And long-term safety studies in humans would address the most significant remaining uncertainty about the compound

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Fibroblast cell-culture studies have characterized proliferation, migration, collagen synthesis, and gene-expression endpoints

Stage 3: Dimples remain visible both standing and lying down

For a full discussion of the development of the multiple imaging composite APC methodology, we refer readers to the CY 2009 OPPS/ASC final rule with comment period (73 FR 68559 through 68569)