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87 , e0054421 (2021)

Inhibition of the Xc-system, inactivation of GPX4 and overloading of iron ions are the three most critical factors leading to ferroptosis

Thus, these related genes constitute a gene family, which includes at least 13 members that have been concisely summarized by Heisterkamp et al

Finally, both DFO and the glutaminolysis inhibitor Compound 968 prevent cell death in an ex vivo model of ischemia/reperfusion injury in the mouse heart [10]

Most notably was the impact of MDA and NO and decreased Gpx and zinc, although PCs and MPO, as well as decreased TAC, all contribute to neuropsychiatric symptoms

(PubMed) Yadav V, Marracci GH, Munar MY, et al