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In Phase I, enzymes use oxygen to modify toxic compounds, often making them temporarily more reactive

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10.3390/ijms22084073 118 LiX

If you have a sensitive stomach, taking them with a small meal is a perfectly acceptable alternative

It can be found that GB and DAA have similarities in the pathways related to the regulation of ferroptosis, both of which may mobilize downstream genes by influencing Nrf2 activity, and finally exert the role of anti-ferroptosis, while achieving a balance of iron metabolism and lipid peroxidation