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This approach not only eliminates the need for the addition of allopurinol, it may even allow further upward titration of thiopurine doses to achieve the desired efficacy with little to no risk of adverse drug reactions (Weyer et al., 2001)

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No serious adverse events were attributed to leucovorin in these studies [8]

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Maternal-fetal transport of immunoglobulin G and its subclasses during the third trimester of human pregnancy