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As expected, and consistent with a reduced interaction of the amidated C-terminal tyrosine with the CTR ECD, CagriP37Y presented a lower potency than Cagri in cells expressing CTR alone (Supplementary Fig

This distinction is crucial for appropriate clinical investigation and management

Moreover, it cannot be excluded that eCATH-1 might be expressed in other cell types than myeloid cells as demonstrated for other members of the cathelicidin family, e.g., the lung [113], squamous epithelia [114], or in cancerous tissues [115]

European Comission (EC)

PMID: 36551977 Chang CH, et al