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However, substantial heterogeneity among studies was observed, likely attributable to differences in dosage, baseline B12 status, and population characteristics
To assess the metabolic stability of the synthesized peptides, serum metabolism studies were conducted using blood obtained from 4-month-old male Sprague-Dawley rats
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Numerous clinical trials, including rigorous randomized placebo-matched control studies, have all failed to show any positive clinical benefit for NSAIDs over placebo for the management of wide- spread pain associated with FMS.7 Even the corticosteroids such as prednisone show no better results than placebo when given to FMS patients.6 Based on these studies, it appears that gross soft-tissue inflammation does not play a major role in the pathogenesis of FMS