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Apart from intrinsic signaling, the TME shapes CSCs behavior and mechanical cures from ECM further modulates CSC fate, with poor stiffness enhancing stemness and high stress leading to quiescence via distinct integrin-dependent pathways
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Several flavonoids additionally exert epigenetic effects (HDAC/DNMT modulation), which may stabilize transcriptional reprogramming of cytoprotective genes (Huang et al., 2023)
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