Furthermore, depletion of GSH, using l-butathione sulfoximate (BSO) 14,15 and TP219 16 , blocks the assembly of protomeric units into pentamers 14,16,17
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Pickart couldnt have predicted the gene expression data when he was watching liver cells in 1973
We propose that these changes might be involved in the disease. Oxidative stress results from the accumulation of free radicals, highly reactive molecules that can damage cells, membranes, lipids, proteins and DNA