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In studies with or without other diabetes medications, weight loss in adults ranged from 12 lb (5 mg) to 25 lb (15 mg)

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In the SURMOUNT trials, 15 mg averaged 22.5 percent body weight loss over 72 weeks, while the 5 mg and 10 mg doses landed roughly in the 15 to 20 percent range

Many patients find their bowel habits gradually normalise as the body adapts to semaglutide, though this adjustment period can take several weeks

The marketing authorisation holders for these medicines will continue to monitor these events closely, including any new publications, as part of their pharmacovigilance activities and report any new evidence on this issue in their Periodic Safety Update Reports (PSURs).