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the same study reported a reduction in cheek fat pads by 69.9% in GLP-1 RA-MWL

[DOI] [PubMed] [Google Scholar] [44].Fediuk DJ, Nucci G, Dawra VK, Cutler DL, Amin NB, Terra SG, Boyd RA, Krishna R, Sahasrabudhe V, Clin Pharmacokinet 2020, 59, 949

Dose adjustments can help maintain momentum, particularly if weight loss begins to stagnate

Long-term adherence is essential to realizing the full therapeutic potential of GLP-1s, yet behavioral factors (such as reaching personal weight goals or perceived social stigma) and systemic issues (like high out-of-pocket costs and fragmented care) disproportionately affect obesity patients

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This is a complex topic we'll explore more below, but our general guidance is to avoid it unless you have a very specific protocol