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Dehydration worsens nausea, and GLP1 medications already increase dehydration risk through reduced appetite and GI side effects

Exendin-4 significantly increased insulin level and phosphorylation of insulin receptor substrate 1 (IRS-1) in rat hippocampus, and could not change the status of tau phosphorylation without insulin in HT22 neurons, suggesting that insulin is required in reduction of tau hyperphosphorylation by GLP-1R agonists (154)

A comprehensive review highlighted the role of DA in cognitive function and emphasized DA dysfunction in DM

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