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No phase II or III randomised controlled trials have been registered with the EMA, MHRA or FDA

Over time, consistent use can lead to firmer, smoother skin with a more youthful appearance

Patients were categorised as: usual care, high on-treatment CRP (2mg/L) or low on-treatment CRP ( 0.1 for all), with a trend towards better functional outcome at 90 days (OR 0.79, 95% CI 0.61-1.03, p = 0.077)

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Lancet 372 , 12401250 (2008)

After glycocalyx degradation, the barrier function of endothelial cells is impaired, further aggravating systemic microcirculatory disorders and organ hypoperfusion [66,67,68]