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Unveiling astrocytic control of cerebral blood flow with optogenetics

Clinical trials show average weight loss of 24.2% of body weight at standard doses over 48 weeks

Some blood pressure medications, birth control pills, and respiratory drugs may cause the problem

doi: 10.1016/j.jad.2012.07.024 38 Almeida-SantosAFKangussuLMMoreiraFASantosRASAguiarDCCampagnole-SantosMJ

For the right patient, medications such as semaglutide and tirzepatide may be useful tools when they are prescribed, monitored, and adjusted as part of a physician-guided plan

Using RT-qPCR we confirmed that both RRM1 and RRM2 were down-regulated after nutlin-3 treatment, with RRM2 down-regulation being entirely p53-dependent and RRM1 regulated by both p53 and p21 (Fig 3C)