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Trans-differentiation of glioma cells to endothelial cells in vitro was demonstrated by culturing of glioma cancer stem cells in endothelial-promoting media, resulting in expression of pan-endothelial markers CD31, CD34 and vWF, formation of tubular structures and uptake of LDL [59, 77]

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Bidirectional Communication Bidirectional communication manifests in multiple experimental paradigms: From brain to gut: Selye-type stress leading to gastroduodenal ulcers was counteracted by BPC-157, which modulated hypothalamic-pituitary-adrenal (HPA) axis function and vagal signaling

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