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Researchers used propensity scores to match the groups with each other based on demographics, cardiovascular and respiratory conditions, endocrine disorders, cardiac medications, BMI, hemoglobin A1C and BNP levels

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A 2024 meta-analysis (Sattar et al., Lancet Diabetes Endocrinol) found that switching from semaglutide to tirzepatide produced an additional 4.2 kg mean weight loss over 40 weeks, even when semaglutide had been titrated to maximum dose