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Conversely, those with specific FTO or MC4R variants might need more aggressive dosing to overcome genetic appetite drive

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In this context, the activity of preproglucagon-expressing neurons in the NTS is stimulated by afferent vagal inputs that relay satiety signals from the periphery to the brain, such as gastric distention, the induction of peripheral GLP-1Rs or the release of the satiety-associated hormones cholecystokinin and leptin

While diarrhea is rarely dangerous, prolonged fluid loss can lead to weakness, dizziness, or elevated heart rate

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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been shown to reduce glycated hemoglobin levels via regulation of incretin function without secondary effects such as weight gain and hypoglycemia [4, 5]