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LOXL2-DM was used as a negative control in this assay, as the LTQ generation is a self-processing reaction that requires copper binding 52,53 that is lacking in the LOXL2-DM 40

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Although patch testing is advised prior to use, typically for those with sensitive or reactive skin, GHK-Cu is generally well tolerated

These numbers come from Astrup and colleagues in the Lancet, 2008, and the later Mexican phase 3 program, which centered on similar dosing

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