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Also, several pathogenic mechanisms linked to ALS involve redox-sensitive proteins, including protein disulfide isomerase (PDI), thioredoxin, and glutathione (GSH), and recent evidence highlights their importance in neurodegeneration

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Selenop / / Scly / mice, indicating exacerbated neurological phenotype compared to Selenop / mice, including motor coordination, audiogenic seizures, and brainstem neurodegeneration

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Engineering new peptides with desired selectivity profiles requires time-consuming and expensive cycles of design-make-test-analyse (DMTA) work

Endocrine Reviews, 1999