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Absence of p53 gene mutations in cutaneous melanoma

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Whereas GH insensitivity, both in humans and in transgenic mice, have only mild retardation of growth at birth as previously stated[3135], IGF-I deficiency in gestational state reveals serious postnatal growth retardation, as has been reported both in humans and in transgenic animal models of IGF-I deletion[3640]

Therefore, for all the reasons explained, arginine has been proposed as an alternative for patients who had already experienced AEs with PDEis

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doi:10.1016/j.jand.2024.10.023 McGinnis A