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Notably, treatment with APR-017 alone affected neither ROS level nor cell viability, while treatment with IC261 alone slightly elevated ROS level and reduced cell viability

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doi:10.22074/cellj.2016.4872 [21] Barreiro E, Snchez D, Gldiz JB, Hussain SN, Gea J

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Because of this origin, it is studied as a potential communicator between mitochondria and the rest of the cell, a role researchers refer to as retrograde mitochondrial signaling

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