Braz, J
3) via activation of EECs or peripheral neurons directly
DPP-4i CVOTs With respect to the primary endpoint (3P-MACE), the CV safety profile of saxagliptin, sitagliptin and linagliptin was established in the respective CVOTs [64,65,66]
Gledhill K, Rhodes LE, Brownrigg M, Haylett AK, Masoodi M, Thody AJ
However, benchmarking against SUSTAIN-6 flagged disagreement for the effect on all-cause mortality, highlighting potential residual confounding for this secondary endpoint that could reflect preferential prescribing in patients for whom clinicians anticipated limited life expectancy
Women that were pregnant, breast-feeding, or had the intention to become pregnant were also excluded from participation