With semaglutide, the primary mechanism is appetite suppression, so ensuring adequate protein intake is critical to minimize lean mass loss during the caloric deficit
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This means the insulinotropic effect is most pronounced when blood glucose is high and diminishes as glucose levels normalize, thereby carrying a very low intrinsic risk of causing hypoglycemia
Still, companies prescribing compounded GLP-1s now seem to be trying to justify the prescriptions based on compounding's second purpose: a need for customized versions of the drugs
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