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Histologic Features Hyperpigmentation of the basal keratinocytes with prominence, but not increase of mostly dendritic melanocytes Subjacent mucosal melanophages and fibrosis Absence of melanocytic nests, cytologic atypia, pagetoid scatter Differential Diagnosis Post-inflammatory hyperpigmentation Lentiginous junctional melanocytic nevus Melanoma in situ Takeaway Essentials Clinical Relevant Pearls Can have variegated color and very irregular contours raising concern for melanoma Pathology Interpretation Pearls Hyperpigmentation of the basal keratinocytes can be subtle Comparing the hyperpigmented areas with the adjacent normal, non-hyperpigmented epidermis may provide the only clue Immunohistochemical/Molecular Findings In difficult cases immunohistochemistry for Mart-1 and/or MiTF-1 can be helpful in excluding melanoma in situ Post-inflammatory Hyperpigmentation Clinical Features Post-inflammatory hyperpigmentation, as the name implies, is pigmentation that occurs in the setting of a genital eruption that has an inflammatory component, particularly one that is directed at the epithelium [7, 35]
This article explains current FDA requirements, reviews risks associated with unapproved products, and outlines how patients and providers can approach semaglutide therapy responsibly
A strategy to incorporate treatment pause, dosing flexibility and education to support GLP-1RA therapy persistence was evaluated in the PIONEER 6 trial
Final Notes This guide aims to provide a meticulous and straightforward method for reconstituting BPC 157, tailored to meet the research community's needs
Liu L, Wang H, Chen X, Zhang Y, Zhang H, Xie P
