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whereas the increase in estrogen was shown to increase the expression of the anti-apoptotic gene (B-cell lymphoma 2) in mice with cerebral ischemia (Dubal et al., Complete smoking cessation is difficult to achieve during pregnancy, especially in certain communities where maternal smoking rates are particularly high (Chertok and Archer, 2016)

The study was conducted in accordance with the ethical principles that have their origins in the Declaration of Helsinki and its subsequent amendments (clinicaltrials.gov identifier NCT02317536)

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This is expected and it is a sign that your body is responding well to the treatment