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- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)

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The retatrutide dosing after high-dose tirzepatide addresses the specific titration considerations when coming from an established GLP-1 protocol

The absence of guidance from professional societies is itself a data point

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It supports generalized growth hormone production, making it a complementary peptide to Tesamorelin