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Effect of SAC on serum metabolites in UC mice To visualize the global metabolic alterations among the three groups, an unsupervised principal component analysis (PCA) was performed on the UHPLC-QTOF-MS dataset

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Finally, we demonstrate that in mice, both the efficacy and tolerability of GLP1R agonists vary with the phase of the estrous cycle, being highest during proestrus (when estrogen levels peak) and lowest in diestrus (low estrogen levels)

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