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Sally Seymour, director of the Division of Pulmonology, Allergy, and Critical Care in the FDAs Center for Drug Evaluation and Research, said in a news release
5.9 Pulmonary Aspiration During General Anesthesia or Deep Sedation MOUNJARO delays gastric emptying [see Clinical Pharmacology (12.2)]
Key factors influencing dose selection include: Treatment goals : Whether the primary aim is glycaemic control, weight reduction, or cardiovascular risk reduction Baseline HbA1c and blood glucose levels : Higher values may eventually require higher maintenance doses Body weight and BMI : Particularly relevant for weight management indications Renal function : Most GLP-1 medications (semaglutide, liraglutide, dulaglutide) do not require dose adjustment for kidney impairment, but exenatide and lixisenatide should be used with caution or avoided in severe renal impairment Concurrent medications : Especially other glucose-lowering agents that might increase hypoglycaemia risk Previous medication tolerance : History of gastrointestinal sensitivity influences titration speed Cardiovascular history : Some GLP-1 medications have proven cardiovascular benefits at specific doses Diabetic retinopathy status : Rapid improvement in blood glucose can temporarily worsen retinopathy, particularly with semaglutide [22] [23] Your doctor will typically schedule regular follow-up appointments during the initial months of treatment
Losartan is also used to reduce the risk of stroke in people with certain health conditions
Relief from obesity-related conditions such as obstructive sleep apnea
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