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[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Frick K.M., Tuscher J.J., Koss W.A., Kim J., Taxier L.R

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However, in contrast to insulin, 5080% of which is metabolized in the liver, establishing a portal-peripheral concentration gradient, other incretins, including amylin and GLP-1, do not undergo a similar first-pass liver extraction effect because parenchymal liver cells do not express GLP-1 and amylin receptors

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This is also now observed in people with type 2 diabetes