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In a Phase 2a trial specifically evaluating liver outcomes, retatrutide achieved an average 82% reduction in liver fat content

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Preclinical studies in rodent models have shown that LAN exposure, increases oxidative DNA damage, disrupts estrogen signaling and accelerates mammary tumor growth 22

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Patient Characteristics Most patients in cohort 1 were female (62.2%), and the mean age was 70.4 years (standard deviation [SD],13.2)

Decades of subsequent research have broadened the picture