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GLP-1RAs make a direct protective impact on the endothelium by the GLP-1R-dependent AMPK/Akt/eNOS pathway [105]

Both options are designed to support appetite control, food noise reduction, and metabolic weight management, but they differ in how they are taken, how consistently patients use them, how they fit into daily life, and how providers think about dose strategy

Bertien Buyse, Alexandros Kalkanis, and Dries Testelmans: writing, reviewing, and editing

The difference in the levels of CYP enzymes may also be related to the specific function of individual P450 enzymes and substrate specificity 73

Rajesh Dhirmalani, a board-certified gastroenterologist and member of Replenza's advisory board

For many people taking GLP1s like Ozempic, Wegovy, or Mounjaro, the changes are striking a reduced appetite, weight loss, smaller meals