GSTT1 and GSTM1 polymorphisms and myelodysplastic syndrome risk: A systematic review and meta-analysis
4 Recently, it has been observed that the human erythrocyte GSTP1-1 (e-GST) is overexpressed in the case of increased blood toxicity as it occurs in healthy subjects living in polluted areas and in nephrologic patients under conservative or dialytic therapies
These illustrations are suggestive of evolutionary selection for activities with these substrates
Due to the deficiency of antioxidant function, melanocytes in vitiligo are particularly sensitive to ROS accumulation, which leads to DNA damage, protein oxidation/breakage, mitochondrial dysfunction, endoplasmic reticulum abnormalities and lipid peroxidation (Rodrigues et al., 2017)
Hence, it has been postulated that quercetin has demonstrated its ability for neuroprotection and anti-inflammation in numerous studies
The cause is unknown, although it seems to be related to stress or anxiety