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In addition, inflammatory response increases the permeability of the alveolar walls, leading to the leakage of fluid and cells from the alveoli and the formation of parenchymal lung lesions (Holloway et al., 2018)
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[15] In both trials, after 72 weeks of treatment, participants who received tirzepatide at all three dose levels experienced a statistically significant reduction in body weight compared to those who received placebo, and greater proportions of participants who received tirzepatide achieved at least 5% weight reduction compared to placebo
By allowing the body to adapt at each 2 mg increment, the trial was able to get subjects up to powerful 8 mg and 12 mg doses with manageable side effects that were mostly mild to moderate and transient
